Pharmacological Profile of Flunarizine: a Calcium Channel Blocker
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چکیده
Flunarizine is a non selective calcium channel antagonist. It is highly lipophilic compound which distributes preferentially in adipose tissue and passes the blood brain barrier readily. Numerous preclinical and controlled clinical studies, including double blind clinical studies in which the drug was compared with placebo or standard drugs in particular disease showing efficacy in migraine, vestibular vertigo, reading epilepsy, generalised epilepsy and Landau-Kleffner syndrome. This review highlights the pharmacodynamics, pharmacokinetics, therapeutic indications, dose and side effects of flunarizine. Although flunarizine is well tolerable drug, some side effects appears which can be avoided by following a special schedule or administration.
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تاریخ انتشار 2014